Dr. Robert Groysman, MD
The Complete
Long COVID Handbook
Seven volumes. Six biological mechanisms. One framework that connects your symptoms, triggers, and root causes to practical treatment strategies, written for patients who deserve real answers, and the clinicians who treat them.
The Seven Volumes
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2nd Edition, Foundation Volume
The Complete Long COVID Handbook
The foundation volume. Maps all six biological mechanisms to symptoms, triggers, and treatment frameworks. The essential starting point for patients and clinicians.
Volume 2
Dysautonomia
When the autonomic nervous system fails to regulate heart rate, blood pressure, and basic bodily functions, the result is a cascade of symptoms that most doctors miss entirely.
Volume 3
Mitochondrial Dysfunction
Profound fatigue, post-exertional malaise, and cognitive impairment often trace back to impaired ATP production at the cellular level. This volume explains why, and what to do.
Volume 4
Gut Dysbiosis & Leaky Gut
A disrupted gut microbiome drives systemic inflammation, nutrient malabsorption, and multi-system symptom amplification. The gut-brain axis is rarely addressed, but often central.
Volume 5
MCAS & Histamine Intolerance
Unpredictable reactions to foods, medications, and environmental triggers. Mast cell activation syndrome is one of the most common and most overlooked mechanisms in Long COVID.
Volume 6
Endothelial Dysfunction & Microclots
Damaged vessel linings and microclot formation restrict oxygen delivery throughout the body. This vascular mechanism explains symptoms that don't respond to conventional treatment.
Volume 7
Hormone Imbalance & Metabolic Dysfunction
Disruptions in testosterone, estrogen, thyroid, and cortisol compound fatigue, mood dysregulation, and metabolic dysfunction. Often the missing piece in an incomplete treatment plan.
Complete Series
Get the full framework.
All seven volumes.
Each volume can be read independently, but together they form a complete system for understanding Long COVID at the biological level. The full series is the most comprehensive resource available for patients and clinicians navigating this condition.
Get the Complete BundleThe Clinical Framework
Long COVID is not one condition.
It is driven by six distinct mechanisms.
Understanding which mechanisms are active in your case is the first step toward effective treatment. Most patients have more than one.
Dysautonomia
Dysfunction of the autonomic nervous system, the system that controls heart rate, blood pressure, digestion, and temperature regulation without conscious effort.
Mitochondrial Dysfunction
Impaired energy production at the cellular level. When mitochondria cannot produce adequate ATP, fatigue and exercise intolerance become the defining symptoms.
Gut Dysbiosis & Leaky Gut
Imbalance of the gut microbiome and breakdown of the intestinal barrier. Impacts immunity, inflammation, and nutrient absorption throughout the body.
MCAS & Histamine
Immune dysregulation where mast cells release excessive histamine and inflammatory mediators, triggering widespread and seemingly unrelated symptoms.
Endothelial Dysfunction
Vascular injury and microclot formation. Damaged blood vessel linings impair blood flow and oxygen delivery, explaining symptoms that resist conventional treatment.
Hormone Imbalance
Disruptions in testosterone, estrogen, thyroid, and cortisol. These hormonal shifts compound fatigue, cognitive issues, and metabolic dysfunction.
Ready to begin?
Start with Volume 1.
The foundation volume introduces all six mechanisms and gives you the framework to understand which ones are driving your symptoms. It's the essential starting point, and it's available now.